Industrial production Essay Example for Free

Industrial production Essay In his empirical study Imai (1996) examined other significant internal factors promoting democratic changes. He demonstrated that industrial production and GDP per capita have gradual lasting influence on their implementation (p. 8). It seems logical as economists argue that with growing size of the developing nation’s market and expansion of its economy, democratization of the country is facilitated. Consequently, as the purchasing capacity of the most population measured by GDP per capita raises, the economic and political liberalization within the developing country is promoted, thus contributing further to the democratization (Armijo, 2005, p. 2019). Imai (1996) also emphasizes that the larger is the size of the developing nations home market, and the more amounts of foreign direct investment the nation draws, the deeper democratic changes it will have to implement together with liberalization of its economy (p. 11). At the same time, increased purchasing capacity of domestic consumers fosters expansion of private entrepreneurship which, for its part, promotes political liberalization, in the long run decreasing the state’s capability to strongly control civil liberties of its citizens (Arblaster, 1999, p. 40). So, as we discussed above, citizens of more economically advanced developing countries enjoy more civil liberties, and what is important to note here, such countries usually demonstrate the trend of growing urban population. At the same time, Imai (1996) proves that number of urban population is one of indicators of the internationalization of national economy, which contributes to democracy facilitation too, and more urbanized developing countries demonstrate more efforts toward democratization (p. 10). These trends evidently show that creation of wealthy stable society in developing countries is one of vital preconditions of democratization. The proper concept of democratization is closely connected with the notion of civil society as democracy constitutes a form of its existence. Formation of constitutional state and real democracy is impossible without civil society’s coming-to-be (Penna, 1998, p. 116). Important aspect of civil society formation is attaining unity among the people. For example, experience of political history of many African states, as well as Yugoslavia of the first half of 1990s, demonstrates that deep disunity of the society on the ground of ethnical features and prevailing separatist trends among the majority of population even in the presence of democratic aspirations in the society may not only become the hindrance to democratization process, but lead to opposite results (Penna, 1998, p.118). A few decades ago scholars entered a new notion into circulation – that of ‘consolidation of democracy’ – which implies irreversibility of established political structures where certainty of the procedures leads to limitation of ‘uncertainty of outcomes’, that is undemocratic outcomes are practically impossible (Randall Svasand, 2001, p. 78). This notion supposes that further democratization of the world is being considered as inevitable, and it is just an issue of time. But the way to this achievement appear to be not easy one. As our study demonstrate, outcome depends on the results of economic reforms which associate with democratization of political regime in minds of major part of population, although direct interrelation of economic and political transformations is not mandatory. That is why incapability of young democracies to satisfy economic interests of poor strata of population often makes a threat for entire democratization process (Petras Veltmeyer, 2001, p. 52).

THe beginning of Seattle history :: essays papers

THe beginning of Seattle history The coast of Washington is rich with the history of early America. While much of the United States was still in its infancy, Washington was thriving with industry. Though the industry was large, the towns were just beginning to grow. Though Washington’s coastal towns offered much to its citizens, it was the logging industry that started it all. In this paper, I will discuss the growth of the logging industry, specifically in relation to Seattle, and the resulting extension industries in the development of what is now our nations largest port city. I. The early industry: The laborers who sat idle during the fur trading off-season were of great concern to George Simpson, resident governor of the Hudson’s Bay Company in 1821. As he sat in his newly transferred building situated on the north bank of the Columbia River, he noticed the commanding view, in which he saw endless stands of thick timber. By order of Simpson, command of the new post, Fort Vancouver, was secured by one John McLoughlin and together, the two established the first Washington timber mill (Ficken 1987). The mill, which began operation in 1828, was charged with the responsibility of supplying timber up and down the southern coast of the United States and where ever markets were deemed profitable. This venture enabled the company to cover expenses throughout the remainder of the year and according to Simpson, â€Å"†¦yielded quite a handsome profit† (Ficken 1987). The mighty Columbia had proven useful in transporting logs to the port in the Puget Sound. The successful Fort Vancouver sawmill constituted the only timber exploitation resource in the Pacific Northwest for over a decade. As the industry became more and more profitable, the inevitable happened, and the Americans came to the Northwest. II. The potential of Seattle is realized: In 1851, Arthur Denny and a small crew built small log shelters on the beach of Elliot Bay. As Denny and his party recognized the availability of timber in the region, they moved camp to the more protected eastern shores of the bay to erect facilities to process the lumber they would soon be harvesting (Ficken 1987). As they laid out their settlement, they called their village Duwamps (later to be know as Seattle). The industry grew and soon mills were showing up all over the coast of Washington.

Nitric Oxide Therapy in infants with pulmonary hypertension

The benefits of nitrogen oxide (NO) therapy as used in the treatment of infants with persistent pulmonary hypertension (PPHN) can be best appreciated if the reader is familiar with the pathophysiology of PPHN and the previous methods used in treating the disease. The function of NO has evolved in the minds of the scientific community from being a mere noxious gas emitted by vehicles to a wonder compound in the field of medicine. In the area of pulmonology, its vasodilatory effect in the blood vessels is now being used to assist PPHN patients in rerouting blood flow in infants whose blood circulation fails to shift from fetal to normal circulation.Such nature of the compound, being the main ingredient in NO therapy allows for a less invasive procedure which in effect reduces risks of complications during and after treatments, expected in previous treatment methods. This reduced risks account for the relatively more cost-effective character of NO therapy as a treatment method in PPHN p atients.There is not much use for the lungs during the fetal life. At such stage, the function of the lungs is carried out by the placenta through the umbilical cord. Fetal life is characterized by a high pulmonary vascular resistance (PVR) with pulmonary blood flow being restricted to a less than 10% lung-directed cardiac output. Blood vessels that connect the heart and the lungs are constricted, sending the circulating blood back to the heart through the ductus arteriosus, a blood vessel that functions only in fetuses. In other words, the lungs in the fetal stage are bypassed.At birth, when the lungs finally assume the function of gas exchange, the PVR decreases, allowing for an increase in pulmonary blood flow. The blood vessel that is previously constricted, favoring blood flow to the ductus arteriosus is now relaxed, simultaneously with the permanent closure of the ductus arteriosus. This happens as the lungs become ventilated and the alveolar oxygen tension is increased.Persis tent Pulmonary Hypertansion occurs when at birth, the lung circulation fails to achieve the normal drop in PVR, preventing the transition from fetal to newborn circulation. This failure results in the continuous functioning of the ductus arteriosus which impairs the flow of blood from the heart to the lungs and limits the amount of oxygen that can be picked up by the blood to be delivered to the different parts of the body. The blood that flows back to the heart remains in an unoxygenated state which could lead to the development of refractory hypoxemia, respiratory distress and acidosis.It is only in 1987 when nitric oxide (NO) was recognized as a key endothelial-derived vasodilator molecule. From then, research has been expanded to establish the role of NO throughout the body, and to discover its therapeutic potential.   To appreciate the effects of NO in alleviating pulmonary hypertension, it is important to gain understanding of its chemistry and mechanism of action.Nitric Oxi de is a gaseous compound that rapidly diffuses across membranes and has a single unpaired electron. This explains its high reactivity, especially to Hemoglobin (Hb) in the blood. This nature of the compound accounts for its noted biological significance. It has been discovered to function as stimulant in the release of hormones; as neurotransmitter; a significant participant in the magnification of synaptic actions and learning processes; and an inhibitor in platelet aggregation, which makes it a marvel in the field of cardiology. In the field of pulmonology, nitric oxide is valued for its vasodilatory effect in the blood vessels.This effect can be explained by the mechanism involving the compound's diffusion from the vascular endothelial cells to the subjacent smooth muscles of the pulmonary vessels. From here, NO activates the enzyme guanylate cyclase to change conformation to promote smooth muscle relaxation by converting GTP to cGMP.   This vasodilatory effect signals the mech anism to modulate blood flow and vascular tone.Given the mechanism of action, it is easy to surmise how NO can be utilized as a therapeutic agent in the management of blood-vessel-related diseases such as those related to the heart (hypertension), the reproductive system(erectile dysfunction) and in this case, the lungs (Persistent Pulmonary Hypertension in infants (PPHN)).Before NO, treatments used in infant PPHN are hyperventilation, continuous infusion of alkali, tube vasodilation and vasodilator drugs. A study on the effects of these various treatments was done by Ellington, Jr., et. al., (2001) showing no specific therapy clearly associated with the reduction in mortality in infants. In determining whether therapies were equivalent, the study showed that hyperventilation reduced the risk of extracorporeal membrane oxygenation (ECMO) with no oxygen increase at 28 days, while alkali infusion increased the use of ECMO as well as an increase in the use of oxygen at 28 days (Ellingt on, Jr., et. al., 2001). ECMO is a highly invasive procedure that requires major surgery, performed in serious cases of PPHN when patients fail to respond to treatments.It is only after post-lab studies were able to identify the role of NO-cGMP signaling in the regulation of lung circulation that NO therapy was developed for PPHN (Channick, R., et. al., 1994). Like previous treatment methods, NO therapy improves oxygenation as well as reduces the risk of ECMO in infants with PPHN (Oliveira, et. al., 2000). But because nitric oxide is capable of acting on its own upon inhalation to relax the blood vessels and improve circulation, it is considered as a less invasive procedure in the management of infants with PPHN compared to the previous treatments mentioned in the preceding paragraphs.The efficiency of the treatment procedure can be determined by observing its effect on the patient's ventilation and blood flow, which is a determinant of the efficiency of transpulmonary oxygenation a nd partial pressure of oxygen in the systemic arterial blood (Ichinose, et. al., 2004). NO therapy enhances the mechanism by which blood flow is redistributed toward regions in the lungs with better ventilation and higher intra-alveolar partial pressure of oxygen (Ichinose, et. al., 2004).Other treatments used in the management of PPHN such as tube ventilation, alkalosis and intravenous vasodilators were shown to be effective in ameliorating pulmonary hypertension in some infants, but in many instances, it does not, as ECMO almost always becomes a necessity in saving the life of the infants (Ichinose, et. al., 2004). A type of hyperventilation has been proven not to increase the risk of ECMO, but unlike NO-therapy (Ellington, Jr., et. al., 2001), it is invasive as to require a tube inserted inside the infant's trachea.In patients with moderate PPHN, there is an improvement in arterial p a O 2, reduced necessity of ventilator support and low risk of progression to severe PPHN (Sadiq, et. al., 2003) and this, without the risk of increasing the incidence of adverse outcomes when the age of 1 year is reached (Clark, et. al. 2003). Inhaled NO is able to rapidly increase the arterial oxygen tension and increase the blood flow in the lungs without causing systemic hypotension (Roberts, 1992; Kinsella, 1992). No apparent increase in morbidity has been shown after one year of treatment with NO (Aparna and Hoskote, 2008). For high-risk infants with PPHN, inhaled NO has been found to lessen the risk of pulmonary hypertensive crisis (PHTC) after congenital heart surgery (Miller, et. al. 2000).Studies on the role of NO in the management of PPHM show that while it is therapeutic, it also prevents the occurrence of chronic lung disease which affects morbidity. Vascular cell proliferation and pulmonary vascular disease have been shown to decrease with NO in the newborn (Roberts, et. al., 1995). In addition, while NO treatment can be more costly, it is the most cost-effective among other methods because of the reduced need for ECMO (Angus, et. al. 2003). For these reasons, it is understandable why NO therapy seems to have taken over in the area of PPHN treatment.ReferencesAngus DC, Clermont G, Watson RS, et al. (2003). Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States. Pediatrics. 112, 1351–1360.Aparna U., Hoskote, MD., et. al. (2008). Airway function in infants treated with inhaled nitric oxide for persistent pulmonary hypertension. Pediatr Pulmonol. 43, 224-235.Channick R, Hoch R, Newhart J, et al. (1994). Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis. Am J Respir Crit Care Med. 149, 811-814Clark, RH., Huckaby, JL., et. al. (2003). Low-Dose Nitric Oxide Therapy for Persistent Pulmonary Hypertension: 1-Year Follow-up. Journal of Perinatology. 23, 300.  Ellington Jr, Marty, O'Reilly, et. al. (2001). C hild Health Status, Neurodevelopmental Outcome, and Parental Satisfaction in a Randomized, Controlled Trial of Nitric Oxide for Persistent Pulmonary Hypertension of the Newborn. Pediatrics,107.Ichinose F, Roberts JD, et.al. (2004). A Selective Pulmonary Vasodilator: Current Uses and Therapeutic Potential. Circulation. 109, 3106-3111. Kinsella JP, Neish SR, Shaffer E, et al. (1992). Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet.   340, 819–820.Miller O, Tang SW, et. al. (2000) Inhaled nitric oxide and prevention of pulmonary hypertension after congenital heart surgery: A randomised double-blind study. The Lancet. 356: 9240, 1464.Oliveira cac, et. al. (2000). Inhaled Nitric oxide in the management of persistent pulmonary hypertension of the newborn: a meta-analysis. Rev. Hosp. Clin. Fac. Med. S., 55 (4): 145-154, 2000Roberts JD Jr, Polaner DM, Lang P, et al. (1992). Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 340, 818–819.Roberts JD Jr, Roberts CT, Jones RC, et al. (1995). Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res. 76, 215-222.  Sadiq HF, Mantych G, et. al. (2003). Inhaled Nitric Oxide in the Treatment of Moderate Persistent Pulmonary Hypertension of the Newborn: A Randomized Controlled, Multicenter Trial. Journal of Perinatology.   23, (2).98

Corruption Of The Saudi Arabia - 906 Words

Corruption in Saudi Arabia According to The Economic Times reports â€Å"corruption in a civilized society is a disease like cancer, which if not detected on time, is surely to spread its malignancy among the polity of the country, leading to disastrous consequences† (Economic Times). Corruption or what it should be called how to destroy a community is the easier and faster way to kill a nation. Unfortunately, corruption is widespread in Saudi Arabia, and an abundance of corrupt people take advantage of their positions to achieve personal goals. Perhaps the most important of their reasons are earning money and having more power because of weak government regulators. This however, has a negative result on various aspects of social life, economic, and political in Saudi Arabia. There are several reasons behind the emergence of the phenomenon of corruption and outbreaks in communities. There is nearly unanimity on the fact that this phenomenon is negative behavior. some of the re asons for people to turn towards to corruption is to make more money, engaging in corruption, and dreaming of more strength. However, the main reason that allows people to engage in corruption and enjoy it is the weakness of government regulation. Corruption leads to the demoralizing aspects of frustration and apathy. Also it will raise the negative spread between the members of the community. Corruption also results in a lack of professionalism the loss of the value of work and a decliningShow MoreRelatedCorruption Of The Saudi Arabia874 Words   |  4 PagesCorruption in Saudi Arabia Referring to The Economic Times report â€Å"corruption in a civilized society is a disease like cancer, which if not detected on time, is surely to spread its malignancy among the polity of the country, leading to disastrous consequences† (Economic Times). 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